The STRING Database in 2025: Protein Networks with Directionality of Regulation
Author Information
Author(s): Szklarczyk Damian, Nastou Katerina, Koutrouli Mikaela, Kirsch Rebecca, Mehryary Farrokh, Hachilif Radja, Hu Dewei, Peluso Matteo E, Huang Qingyao, Fang Tao, Doncheva Nadezhda T, Pyysalo Sampo, Bork Peer, Jensen Lars J, von Mering Christian
Primary Institution: University of Zurich
Conclusion
The STRING database has been updated to include a new regulatory network that allows users to visualize and access distinct types of protein interactions.
Supporting Evidence
- STRING integrates protein-protein interaction data from various experimental and computational sources.
- The new regulatory network mode allows for the visualization of directed interactions between proteins.
- STRING provides tools for network clustering and pathway enrichment analysis.
- The database supports cross-species transfer of protein information.
- STRING's scoring system ensures that data from diverse sources are comparable.
Takeaway
STRING is a tool that helps scientists understand how proteins interact with each other, and the latest version makes it easier to see how these interactions work in different directions.
Methodology
The STRING database compiles protein-protein association information from various sources, including experimental assays and computational predictions, and introduces a new regulatory network mode.
Limitations
The database may lack fine-grained resolution for specific interactions compared to specialized databases.
Digital Object Identifier (DOI)
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