Improving Stability and Bioavailability of Ramipril with MUPS
Author Information
Author(s): Patel HP, Patel JK, Patel MP, Patel RR
Primary Institution: Torrent Research Centre, Gandhinagar, Gujarat, India
Hypothesis
Can a multiple unit particle system (MUPS) enhance the stability and bioavailability of ramipril?
Conclusion
The study found that MUPS of ramipril showed significantly improved stability and bioavailability compared to conventional formulations.
Supporting Evidence
- Ramipril pellets showed only 2.07% related impurities after 6 months, compared to 15.15% in simple formulations.
- MUPS achieved 100.4% dissolution of ramipril and 97.9% of hydrochlorothiazide within 60 minutes.
- The study demonstrated that MUPS can effectively minimize the degradation of ramipril during storage.
Takeaway
This study shows that a special type of medicine called MUPS can help make a heart medicine called ramipril work better and last longer.
Methodology
The study involved the formulation of ramipril pellets using various excipients and methods, followed by stability and dissolution testing.
Limitations
The study primarily focused on the formulation aspects and did not include extensive clinical trials.
Digital Object Identifier (DOI)
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