Foot-and-Mouth Disease Virus Persistence in Germinal Centres
Author Information
Author(s): Juleff Nicholas, Windsor Miriam, Reid Elizabeth, Seago Julian, Zhang Zhidong, Monaghan Paul, Morrison Ivan W., Charleston Bryan
Primary Institution: Pirbright Laboratory, Institute for Animal Health, Woking, Surrey, United Kingdom
Hypothesis
FMDV locates rapidly to, and is maintained in, the light zone of germinal centres following primary infection of naïve cattle.
Conclusion
FMDV is maintained in germinal centres, contributing to long-lasting antibody responses.
Supporting Evidence
- FMDV genome was detected consistently in germinal centres of various lymphoid tissues.
- FMDV capsid proteins were localized to the light zone of germinal centres.
- The study used advanced techniques like laser capture microdissection and quantitative rRT-PCR.
Takeaway
Foot-and-mouth disease virus can hide in special areas of the immune system for a long time, helping the body remember how to fight it off.
Methodology
Laser capture microdissection and quantitative real-time reverse transcription polymerase chain reaction were used to detect FMDV in tissue samples.
Limitations
The study did not detect viral RNA in epithelial compartments of tissues examined.
Participant Demographics
Cattle infected with FMDV isolates.
Statistical Information
P-Value
p=0.0014
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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