Quality Control Material for Plasma Fibrinogen Test
Author Information
Author(s): Masahiro Okuda, Yahiro Uemura, Noriyuki Tatsumi
Primary Institution: Sysmex Corporation
Hypothesis
This study aimed to develop a quality control material using purified human fibrinogen and compare its measurement precision with that of plasma materials.
Conclusion
The study found that purified fibrinogen materials provided superior precision for fibrinogen measurement compared to plasma materials.
Supporting Evidence
- Purified fibrinogen clottability was greater than 95%.
- Coefficient of variation for purified materials was 0.7-3.5%, compared to 1.2-5.3% for plasma materials.
- The purified material was free of contaminants and showed good stability after reconstitution.
Takeaway
Scientists made a special material from pure fibrinogen to help labs measure blood proteins better, and it worked really well!
Methodology
Purified fibrinogen was prepared and its precision was evaluated using automated coagulation analysers.
Limitations
The study did not address the long-term stability of the purified materials beyond 12 hours.
Participant Demographics
Plasma collected from 56 healthy donors.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website