Discrimination of Colon-Derived Liver Metastasis and Primary Tumors by S100 Proteins
Author Information
Author(s): Melle Christian Ernst, Günther Schimmel, Bettina Bleul, Annett von Eggeling, Ferdinand Bauer
Primary Institution: Friedrich Schiller University, Jena, Germany
Hypothesis
Can the protein patterns of tumors change during metastasis, and are there markers that allow metastases to be allocated to a specific tumor entity?
Conclusion
S100A6 and S100A11 can be used to discriminate between different tumor entities, specifically between colorectal carcinoma and hepatocellular carcinoma.
Supporting Evidence
- S100A6 and S100A11 can significantly discriminate between colorectal carcinoma and hepatocellular carcinoma.
- Both proteins were localized in cells using immunohistochemistry.
- Proteomic analysis identified 49 differentially expressed signals in the study.
Takeaway
The study found that two proteins, S100A6 and S100A11, can help doctors tell different types of cancer apart, especially when the original cancer is unknown.
Methodology
Tissue from colon-derived liver metastases was classified, laser-microdissected, and analyzed by ProteinChip arrays.
Limitations
The study does not address how protein patterns change during metastasis or the clinical implications of these findings.
Participant Demographics
Human samples from liver metastases derived from colorectal cancer.
Statistical Information
P-Value
3.00×10−9
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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