Measuring Monocyte Tissue Factor Activity in Cancer Patients
Author Information
Author(s): Lwaleed B A, Chisholm M, Francis J L
Primary Institution: University Department of Haematology, Southampton, UK
Hypothesis
Monocyte tissue factor (mTF) levels can be used to assess tumor presence and progression in cancer patients.
Conclusion
Monocyte tissue factor levels are elevated in patients with malignant and inflammatory diseases compared to controls, and may help identify high-risk individuals.
Supporting Evidence
- Malignant groups showed higher mTF levels than controls for both breast and colorectal cancer.
- Benign inflammatory groups also had higher mTF levels than controls.
- Stimulated cells provided better discrimination between malignant and benign groups.
Takeaway
This study found that certain levels in blood cells can help doctors tell if someone has cancer or how serious it is.
Methodology
A two-stage kinetic chromogenic assay was used to measure mTF levels in various patient groups and controls.
Participant Demographics
Included normal subjects, patients with benign and malignant breast and colorectal diseases.
Statistical Information
P-Value
p<0.001 for stimulated breast cancer cells
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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