Phase III Trial of Albumin in Malaria Still Lacks Scientific Justification
2007
Albumin in Malaria: A Critical Review
publication
Evidence: low
Author Information
Author(s): Woodrow Charles J, Timothy Planche
Primary Institution: St. George's University of London
Conclusion
The study found no significant difference in death rates or other outcomes between albumin and Gelofusine in children with severe malaria.
Supporting Evidence
- No difference was found in death rate or any other outcome measure between the two arms of this study.
- The notion of albumin's superiority over Gelofusine is groundless given the lack of statistical evidence.
- None of the studies on albumin performed in Kilifi incorporated necessary design elements.
Takeaway
The study looked at using albumin for treating severe malaria but found it didn't work better than another treatment called Gelofusine.
Potential Biases
The authors noted inaccuracies in previous studies and the potential for misleading conclusions.
Limitations
The study did not incorporate necessary elements for phase III studies and lacked a clear hypothesis.
Digital Object Identifier (DOI)
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