Meta-analysis of the N363S Polymorphism and Obesity
Author Information
Author(s): Marti Amelia, Ochoa M Carmen, Sánchez-Villegas Almudena, Martínez J Alfredo, Martínez-González Miguel Angel, Hebebrand Johannes, Hinney Anke, Vedder Helmut
Primary Institution: University of Navarra
Hypothesis
Is there an association between the N363S polymorphism of the glucocorticoid receptor gene and obesity risk?
Conclusion
The study found no compelling evidence that the N363S polymorphism of the GRL gene is associated with average BMI or obesity risk.
Supporting Evidence
- The meta-analysis included data from 5,909 individuals.
- The overall estimation of BMI difference was +0.18 kg/m2 for carriers of the 363S allele.
- Statistically significant differences in BMI were found in certain subgroups.
- The pooled odds ratio for obesity linked to the N363S polymorphism was not statistically significant.
- Population-specific effects were noted in the analysis.
Takeaway
This study looked at a gene that might affect weight, but it turns out it doesn't really make people heavier or more likely to be obese.
Methodology
A meta-analysis combining data from 12 published studies and 3 new case-control studies to assess the association between the N363S polymorphism and obesity.
Potential Biases
Potential biases due to differences in age, sex, and ethnic backgrounds of study participants.
Limitations
The study's findings may be influenced by population-specific effects and the variability in BMI definitions across studies.
Participant Demographics
Participants included children, adolescents, and adults from Spain and Germany, primarily Caucasian.
Statistical Information
P-Value
1.02
Confidence Interval
95% CI: 0.56–1.87
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website