Red Blood Cells as Gender-Associated Biomarkers in Metabolic Syndrome
Author Information
Author(s): Elisabetta Straface, Lucrezia Gambardella, Antonella Mattatelli, Emanuele Canali, Francesca Boccalini, Luciano Agati, Walter Malorni
Primary Institution: Istituto Superiore di SanitÃ
Hypothesis
Can red blood cell parameters serve as gender-associated bioindicators in patients with metabolic syndrome?
Conclusion
The study found significant gender differences in red blood cell parameters among patients with metabolic syndrome, suggesting their potential as biomarkers.
Supporting Evidence
- Red blood cell parameters showed significant gender differences in patients with metabolic syndrome.
- Men with metabolic syndrome had a higher percentage of altered red blood cells compared to women.
- Phosphatidylserine externalization was significantly higher in red blood cells from men with metabolic syndrome.
Takeaway
This study looked at blood cells to see if they can tell us something about men and women with a health problem called metabolic syndrome.
Methodology
The study analyzed red blood cell parameters in patients with metabolic syndrome and healthy donors using flow cytometry and microscopy.
Limitations
The study was a pilot with a small sample size and further research is needed to validate the findings.
Participant Demographics
56 patients with metabolic syndrome (31 men and 25 women) aged 50-70 years, and 40 age-matched healthy donors (22 men and 18 women), all Caucasian.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website