Discovering HDAC class II selective inhibitors by multidisciplinary approach
2011
Finding Selective Inhibitors for HDAC7
Sample size: 960
publication
Author Information
Author(s): Lorenzi S, Beccari A, Carettoni D, Rubino M, Nardese V
Primary Institution: Dompé spa
Hypothesis
The study aims to discover selective inhibitors for the HDAC7 enzyme using a multidisciplinary approach.
Conclusion
The study successfully filtered a large database to identify potential inhibitors for HDAC7.
Supporting Evidence
- The study filtered a database of 7 million compounds to find potential inhibitors.
- 960 compounds were purchased and tested against HDAC7.
Takeaway
Researchers are trying to find special medicines that can stop a specific enzyme called HDAC7 from working, which is important for controlling how our genes behave.
Methodology
The study used ligand-based and structure-based approaches to filter compounds from a database and tested them against HDAC7.
Digital Object Identifier (DOI)
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