Evaluation of binding property of mucilage from Litsea glutinosa
2010
Binding Properties of Mucilage from Litsea Glutinosa
Sample size: 100
publication
Evidence: moderate
Author Information
Author(s): Sunil K. Mishra, A. Kumar, A. Talukdar
Primary Institution: Institute of Technology, Banaras Hindu University
Hypothesis
The study investigates the binding properties of mucilage obtained from Litsea glutinosa in tablet manufacturing.
Conclusion
Concentrations of 6% to 8% of L. glutinosa mucilage are better binding agents for tablet preparation compared to starch.
Supporting Evidence
- The mucilage content from the bark of L. glutinosa was found to be 38% w/w.
- Tablets made with 10% mucilage showed more hardness than those made with starch.
- Drug release from tablets with 4%, 6%, and 8% mucilage was more than 85% in 180 minutes.
Takeaway
This study shows that a sticky substance from a tree can help make stronger tablets than a common ingredient used in tablets.
Methodology
Mucilage was isolated from the bark of Litsea glutinosa and evaluated for binding properties in tablets and granules using paracetamol as a model drug.
Digital Object Identifier (DOI)
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