Prognostic significance of hemoglobin, albumin, lymphocyte and platelet score in solid tumors: a pooled study
2024

HALP Score and Cancer Survival

Sample size: 17049 publication 10 minutes Evidence: high

Author Information

Author(s): Li Jinze, Zheng Jing, Wang Puze, Lv Dong

Primary Institution: People’s Hospital of Deyang City, Chengdu University of Traditional Chinese Medicine, Deyang, China

Hypothesis

The HALP score can serve as a prognostic indicator for survival outcomes in patients with solid tumors.

Conclusion

High HALP scores are associated with better survival outcomes in patients with solid tumors.

Supporting Evidence

  • Elevated HALP score was significantly associated with favorable overall survival.
  • HALP score is a potential prognostic biomarker in solid tumors.
  • Subgroup analyses revealed consistent prognostic impact of HALP across different cancer types.

Takeaway

If you have higher levels of hemoglobin, albumin, lymphocytes, and platelets, you might live longer if you have cancer.

Methodology

A meta-analysis was conducted following PRISMA guidelines, pooling data from studies that reported risk ratios and confidence intervals.

Potential Biases

Potential bias due to the retrospective nature of most studies and variability in HALP cut-off values.

Limitations

The majority of included studies were retrospective, which increases the risk of bias.

Participant Demographics

Included 17,049 patients with various solid tumors from multiple countries.

Statistical Information

P-Value

<0.01

Confidence Interval

95% CI 0.54-0.67

Statistical Significance

p<0.01

Digital Object Identifier (DOI)

10.3389/fimmu.2024.1483855

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