FTO in Health and Disease
Author Information
Author(s): Benak Daniel, Sevcikova Anezka, Holzerova Kristyna, Hlavackova Marketa
Primary Institution: Laboratory of Developmental Cardiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia
Hypothesis
The review aims to consolidate current understanding regarding the implications of FTO in health and disease, particularly its role in obesity and related non-communicable diseases.
Conclusion
FTO plays a critical role in the regulation of body weight and fat mass through complex mechanisms involving appetite regulation, energy balance, and adipogenesis.
Supporting Evidence
- FTO is associated with obesity and various diseases such as diabetes and cardiovascular disease.
- FTO influences appetite regulation and energy balance, which are critical in obesity.
- Genetic variants in FTO are linked to increased risk of type 2 diabetes and other metabolic disorders.
- FTO's role in cancer is complex, acting as both an oncogene and an anti-oncogene depending on the context.
Takeaway
FTO is a protein that helps control how our bodies manage fat and energy, and understanding it better could lead to new ways to treat obesity and related diseases.
Methodology
This is a review article summarizing existing research on FTO's role in various health conditions.
Limitations
The review does not provide exhaustive accounts of all studies related to FTO, focusing instead on illustrative insights.
Digital Object Identifier (DOI)
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