Androgen Receptor CAG Repeat Polymorphism and X-Inactivation in Recurrent Spontaneous Abortions
Author Information
Author(s): Aruna Meka, Dasgupta Shilpi, Sirisha Pisapati V. S., Andal Bhaskar Sadaranga, Tarakeswari Surapaneni, Singh Lalji, Reddy B. Mohan
Primary Institution: Indian Statistical Institute
Hypothesis
Longer CAG repeat length (resulting in hyperandrogenemia) would be associated with recurrent spontaneous abortions (RSA).
Conclusion
The study found that longer CAG repeat lengths are associated with increased odds for recurrent spontaneous abortions in Indian women.
Supporting Evidence
- RSA cases had a significantly greater frequency of allele sizes in the polymorphic range above 19 repeats.
- Statistical power for the study was estimated to be approximately 90%.
- Longer CAG repeat lengths were associated with increased odds of RSA.
Takeaway
Women who have more repeats of a certain gene are more likely to have repeated miscarriages.
Methodology
The study involved genotyping CAG repeats of the Androgen Receptor gene and analyzing X-chromosome inactivation patterns in blood samples from RSA cases and controls.
Limitations
The study did not obtain serum androgen profiles to verify biochemical hyperandrogenism.
Participant Demographics
117 RSA women aged 18-37 and 224 control women matched for age, ethnicity, and socioeconomic status.
Statistical Information
P-Value
0.006 for CAG repeats >19, 0.002 for biallelic mean ≥21
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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