Gender Differences in Willingness to Participate in Alzheimer's Clinical Trials
Author Information
Author(s): Lidia Canals-Gispert, Alba Cañas-Martínez, Gema Huesa, Marc Suárez-Calvet Alomà, Marta Milà-Alomà, Eider Arenaza-Urquijo, Davide Cirillo, Annemarie Schumacher Dimech, Florencia Iulita Maria, Julie Novakova Martinkova, Maria Carmela Tartaglia, Frances-Catherine Quevenco, Antonella Santuccione Chadha, Gonzalo Sánchez-Benavides, Carolina Minguillón, Maria Teresa Ferretti, Karine Fauria
Primary Institution: Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain
Hypothesis
The study aims to analyze gender differences in sociodemographic factors associated with the willingness to participate in clinical trials for Alzheimer's disease.
Conclusion
The study found that women are less willing than men to participate in clinical trials and undergo related procedures, highlighting the need for gender-sensitive recruitment strategies.
Supporting Evidence
- Women were significantly younger and had lower educational attainment compared to men.
- Single women were less willing to participate in clinical trials than single men.
- Women with higher education were less willing to undergo lumbar puncture.
Takeaway
This study shows that women are less likely to join Alzheimer's research trials than men, especially if they are single or have lower education.
Methodology
The study involved 2544 cognitively unimpaired participants contacted via phone to assess their willingness to participate in clinical trials and undergo procedures.
Potential Biases
Potential social desirability bias may affect responses, particularly regarding gender differences.
Limitations
The study's limitations include a gap in updating sociodemographic data and reliance on hypothetical scenarios for willingness to participate.
Participant Demographics
Participants were aged 45-75, with 63.1% being women and varying levels of education and marital status.
Statistical Information
P-Value
p=0.003 for willingness to participate in clinical trials; p<0.001 for willingness to undergo lumbar puncture.
Confidence Interval
[1.07–21.18] for gender and marital status interaction.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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