Correction: MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus
2011
MicroRNA 144 and Insulin Signaling in Type 2 Diabetes
publication
Author Information
Author(s): Karolina Dwi Setyowati Armugam, Arunmozhiarasi Tavintharan Subramaniam Wong, Michael T. K. Lim, Su Chi Sum Chee Fang, Jeyaseelan Kandiah
Conclusion
MicroRNA 144 is up-regulated in Type 2 Diabetes and affects insulin signaling.
Supporting Evidence
- A separate miRNA profiling study showed 62 dysregulated miRNAs in Type 2 Diabetes individuals.
- miR-144 was found to be highly up-regulated in T2D samples with a fold change of 2.6.
Takeaway
MicroRNA 144 is like a tiny switch that can make it harder for our body to use insulin when we have Type 2 Diabetes.
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