Genetic Factors Linked to Osteonecrosis of the Femoral Head
Author Information
Author(s): Kim Hye-Ok, Cho Chang-Hoon, Cho Yoon-Je, Cho Seong-Ho, Yoon Kyung-Sik, Kim Kang-Il
Primary Institution: Kyung Hee University School of Medicine
Hypothesis
Are PAI-1 genetic polymorphisms associated with increased risk of osteonecrosis of the femoral head?
Conclusion
Three SNPs of the PAI-1 gene were found to be associated with an increased risk of osteonecrosis of the femoral head.
Supporting Evidence
- The 4G allele of rs1799889, A allele of rs2227631, and C allele of rs11178 were significantly associated with increased ONFH risk.
- An association between the three SNPs and increased risk of ONFH was found only in men.
- In the idiopathic subgroup, rs2227631 and rs11178 were associated with increased risk of ONFH.
Takeaway
This study found that certain genetic changes can make people more likely to develop a serious bone disease in their hip.
Methodology
Genotyping of three SNPs in PAI-1 was performed in 206 ONFH patients and 251 control subjects using direct sequencing and TaqMan assays.
Limitations
The study had a small sample size for steroid-induced ONFH and did not find significant associations in women.
Participant Demographics
206 ONFH patients (159 men, 47 women; mean age 44.2) and 251 control subjects (193 men, 58 women; mean age 47.8).
Statistical Information
P-Value
p = 0.002 - 0.03
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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