From nature to clinic: Quercetin’s role in breast cancer immunomodulation
2024

Quercetin’s Role in Breast Cancer Immunomodulation

publication Evidence: moderate

Author Information

Author(s): Fang Liguang, Gao Dandan, Wang Tong, Zhao Haijun, Zhang Yanan, Wang Shijun

Primary Institution: Shandong University of Traditional Chinese Medicine

Hypothesis

Quercetin can enhance the efficacy of immunotherapy for breast cancer by modulating the immune microenvironment.

Conclusion

Quercetin is highlighted as a natural immunomodulator that enhances immune cell activity and has the potential to be developed as an adjunct for breast cancer treatment.

Supporting Evidence

  • Quercetin enhances the activity of immune cells in the tumor microenvironment.
  • It inhibits tumor angiogenesis and reduces lactic acid production in tumor cells.
  • Quercetin can improve the efficacy of immunotherapy by modulating systemic inflammation.
  • It regulates the composition of intestinal microbiota, which can affect treatment outcomes.

Takeaway

Quercetin is a natural substance that helps the body's immune system fight breast cancer better.

Methodology

The study is a review of pharmacological research on quercetin's effects on anti-tumor immunity in breast cancer.

Limitations

Challenges in clinical application include low absorption rates and unknown effective doses of quercetin.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.3389/fimmu.2024.1483459

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