Butyrolactone-I from Marine Fungal Metabolites Mitigates Heat Stress in Cells and Mice
Author Information
Author(s): Niu Xueting, Chen Shengwei, Wang Xinchen, Wen Jiaying, Liu Xiaoxi, Yong Yanhong, Yu Zhichao, Ma Xingbing, Abd El-Aty A. M., Ju Xianghong, Degl’Innocenti Donatella, Vasarri Marzia
Primary Institution: Marine Medical Research and Development Centre, Shenzhen Institute of Guangdong Ocean University
Hypothesis
Can Butyrolactone-I (BTL-I) alleviate heat-stress-induced apoptosis in intestinal cells and mice?
Conclusion
BTL-I shows potential to improve resilience to heat stress in animals by reducing apoptosis and oxidative stress.
Supporting Evidence
- BTL-I reduced apoptosis-related protein levels in heat-stressed cells.
- BTL-I inhibited oxidative stress markers and enhanced antioxidant activity.
- BTL-I modulated the ROS/PERK/CHOP signaling pathway to mitigate heat stress effects.
Takeaway
This study found that a natural compound from deep-sea fungi can help protect animals from the harmful effects of heat stress.
Methodology
The study used in vitro (IPEC-J2 cells) and in vivo (mice) models to assess the effects of BTL-I on heat stress-induced apoptosis and oxidative stress.
Limitations
The study does not address the long-term effects of BTL-I or its practical application in livestock production.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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