Study of Melanoma in Chinese Patients
Author Information
Author(s): Chi Zhihong, Li Siming, Sheng Xinan, Si Lu, Cui Chuanliang, Han Mei, Guo Jun
Primary Institution: Peking University School of Oncology, Beijing Cancer Hospital & Institute
Hypothesis
Malignant melanoma diagnosed in non-Caucasian populations differs from those diagnosed in endemic regions.
Conclusion
Most malignant melanoma patients in China were diagnosed with locally advanced disease, and their prognoses were suboptimal.
Supporting Evidence
- The 5-year overall survival rate of all 522 patients was 41.6%.
- ALM and MCM are the two most commonly diagnosed pathological subtypes.
- Clinical staging and presence of ulceration were significantly associated with clinical outcomes.
Takeaway
This study looked at melanoma in Chinese patients and found that many are diagnosed late, which makes it harder to treat.
Methodology
A database was established to collect demographic and clinical data from patients with pathologically diagnosed malignant melanoma, followed by statistical analyses including survival and multivariate analyses.
Potential Biases
Potential referral bias as patients were treated at a specialized center.
Limitations
Incomplete data on Breslow thickness and ulceration status due to the rarity of melanoma in the region.
Participant Demographics
{"age":{"≤ 65":429,"> 65":93},"gender":{"male":276,"female":246}}
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 3.282 to 4.558
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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