Clinical Characteristics and Treatment in Pemphigus Patients
Author Information
Author(s): Natalia Welc, Sandra Ważniewicz, Paweł Głuszak, Maciej Spałek, Agnieszka Seraszek-Jaros, Magdalena Jałowska, Marian Dmochowski
Primary Institution: Department of Dermatology, Poznan University of Medical Sciences, Poland
Hypothesis
This study aimed to assess clinical characteristics, comorbidities, medication, and treatment of various types of pemphigus in patients.
Conclusion
Patients with pemphigus often have significant comorbidities and require a multidisciplinary approach for treatment.
Supporting Evidence
- 79.31% of patients were diagnosed with pemphigus vulgaris (PV) and 26.09% with pemphigus foliaceus (PF).
- The most common comorbidities were arterial hypertension, hypercholesterolemia, and diabetes mellitus.
- 90% of PV patients and 94% of PF patients were treated with systemic glucocorticosteroids.
- More than half of the patients received at least one glucocorticosteroid-sparing treatment.
- A significant correlation was found between IgG deposits in DIF and anti-DSG1 antibodies in ELISA testing.
- The mean age at diagnosis was 56.89 years, with PV patients diagnosed at 55.22 years and PF patients at 61.56 years.
Takeaway
Pemphigus is a rare skin disease that can be very serious, and patients often have other health problems that need to be treated together with their skin condition.
Methodology
Data were collected from 69 patients treated in the Department of Dermatology from 2016 to 2023, including demographic and clinical information.
Potential Biases
The study may not represent milder cases typically managed in outpatient settings.
Limitations
The study was conducted at a single center and lacked longitudinal follow-up for all patients.
Participant Demographics
The study group comprised 41 women and 28 men, with a mean age of 56.89 years.
Statistical Information
P-Value
p = 0.0217; p = 0.0031; p = 0.0298; p = 0.0054; p = 0.0339
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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