Clinical Outcomes of Intraoperative Radiation Therapy for Extremity Sarcomas
Author Information
Author(s): Tran Quy N. H., Kim Anne C., Gottschalk Alexander R., Wara William M., Phillips Theodore L., O'Donnell Richard J., Weinberg Vivian, Haas-Kogan Daphne A.
Primary Institution: University of California, San Francisco
Hypothesis
We sought to explore the efficacy of intraoperative radiation therapy (IORT) in the treatment of soft tissue sarcomas of the extremities.
Conclusion
IORT used as a boost to EBRT provides excellent local control for patients with soft tissue sarcomas of the extremities, with limited acute toxicities.
Supporting Evidence
- Gross total resections were achieved in all 17 patients.
- Thirty-six month estimates for locoregional control, disease-free survival, and overall survival were 86%, 50%, and 78%, respectively.
- IORT was extremely well tolerated, with no toxicities referable to IORT.
Takeaway
Doctors used a special kind of radiation during surgery to help patients with tumors in their arms and legs, and it worked really well without making them sick.
Methodology
This retrospective study analyzed 17 patients treated with IORT for soft tissue sarcomas between 1995 and 2001, measuring local control, disease-free survival, and overall survival.
Limitations
The study is limited by its retrospective nature, small sample size, diverse histologies, and various treatment techniques.
Participant Demographics
The median age of participants was 37 years, with 5 patients aged 18 or younger.
Digital Object Identifier (DOI)
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