Modulatory Effects of Polyphenols on Apoptosis Induction: Relevance for Cancer Prevention
2008
Polyphenols and Their Effects on Cancer Prevention
publication
Evidence: moderate
Author Information
Author(s): D'Archivio Massimo, Santangelo Carmela, Scazzocchio Beatrice, Filesi Rosaria, Masella Carmela, Giovannini Claudio
Primary Institution: National Centre for Food Quality and Risk Assessment, Istituto Superiore di SanitÃ
Hypothesis
Can polyphenols modulate apoptosis to prevent cancer?
Conclusion
Polyphenols can induce apoptosis in cancer cells, potentially preventing cancer development.
Supporting Evidence
- Polyphenols can suppress cancer cell growth and induce apoptosis.
- Resveratrol is highlighted for its ability to regulate multiple cellular events associated with cancer.
- Tea polyphenols have shown anticarcinogenic activity in various cancer cell types.
- Polyphenols can modulate oxidative stress, influencing cancer cell survival and death.
- Different polyphenols can have both antioxidant and pro-oxidant effects depending on their concentration.
Takeaway
Eating fruits and vegetables with polyphenols can help your body fight cancer by making bad cells die.
Methodology
The review discusses various mechanisms by which polyphenols affect apoptosis in cancer cells.
Limitations
Most data is derived from in vitro studies, and more research is needed to confirm effectiveness in humans.
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