Effect of cerium lanthanide on Hela and MCF-7 cancer cell growth in the presence of transferring
2010
Effect of Cerium on Cancer Cell Growth
publication
Evidence: moderate
Author Information
Author(s): Abbasali Palizban, Sadeghi-aliabadi H., Abdollahpour F.
Primary Institution: Isfahan University of Medical Sciences
Hypothesis
The study aims to elucidate the possible pathways for the cytotoxic effect of cerium in the presence of apo-transferrin on Hela and MCF-7 cancer cell lines.
Conclusion
Cerium compounds can inhibit the growth of cancer cells, especially when combined with transferrin.
Supporting Evidence
- Cerium has a cell-proliferation inhibitory activity which is significantly increased by transferrin protein.
- The presence of transferrin assisted inhibition of cell proliferation by 20% and 40% in Hela and MCF-7 cells, respectively.
- Apo-transferrin could lightly induce cell growth particularly in MCF-7 cells by itself, but this did not overcome cerium's inhibitory activity.
Takeaway
Cerium can help stop cancer cells from growing, especially when it works with a protein called transferrin.
Methodology
The study used MTT assays to measure cell viability after treating Hela and MCF-7 cells with different concentrations of cerium in the presence and absence of transferrin.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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