DNA Content and Survival in Colorectal Cancer
Author Information
Author(s): N.C. Armitage, K.C. Ballantyne, D.F. Evans, P. Clarke, J. Sheffield, J.D. Hardcastle
Primary Institution: University Hospital, Nottingham; St Mark's Hospital, London
Hypothesis
Does tumour cell DNA content (ploidy) influence survival in colorectal cancer patients?
Conclusion
Tumour cell DNA ploidy is an independent factor in determining patient survival after resection for colorectal cancer.
Supporting Evidence
- 51% of tumors had abnormal DNA content.
- Patients with abnormal DNA had a 32% survival rate compared to 43% for those with normal DNA.
- Pathological stage, local tumor extension, and DNA ploidy were independent prognostic indicators.
Takeaway
This study found that patients with abnormal DNA in their tumors tend to live shorter lives than those with normal DNA.
Methodology
The study analyzed DNA content in tumor samples from 416 colorectal cancer patients who underwent surgery, using flow cytometry.
Limitations
The study is retrospective and may not account for all variables affecting survival.
Participant Demographics
Patients included were those who had resections for colorectal cancer between 1973 and 1977.
Statistical Information
P-Value
0.02
Statistical Significance
p=0.02
Want to read the original?
Access the complete publication on the publisher's website