Soybean-derived Bowman-Birk inhibitor protects neurons from inflammation
Author Information
Author(s): Li Jieliang, Ye Li, Cook Denise R, Wang Xu, Liu Jinping, Kolson Dennis L, Persidsky Yuri, Ho Wen-Zhe
Primary Institution: Temple University School of Medicine
Hypothesis
Does the Bowman-Birk inhibitor (BBI) inhibit LPS-mediated macrophage activation and reduce neurotoxicity?
Conclusion
BBI protects neurons from neurotoxicity mediated by activated macrophages through its anti-inflammatory properties.
Supporting Evidence
- BBI pretreatment significantly inhibited LPS-mediated induction of pro-inflammatory cytokines and reactive oxygen species.
- Supernatant from BBI-pretreated macrophages was less cytotoxic to neurons than that from non-BBI-pretreated macrophages.
- BBI treatment reduced ROS production in LPS-activated macrophages.
Takeaway
This study shows that a substance from soybeans can help protect brain cells from damage caused by inflammation.
Methodology
The study used mixed cortical neural cultures from rats and measured neuronal survival and cytokine expression after treating macrophages with LPS and BBI.
Participant Demographics
Fetal Sprague Dawley rat embryos were used for cortical neural cultures.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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