Intrinsic Disorder in Hub Proteins from Eukaryotic Interactomes
Author Information
Author(s): Haynes Chad, Oldfield Christopher J, Ji Fei, Klitgord Niels, Cusick Michael E, Radivojac Predrag, Uversky Vladimir N, Vidal Marc, Iakoucheva Lilia M
Primary Institution: The Rockefeller University
Hypothesis
Intrinsic structural disorder may be an important attribute that can distinguish between hub and end proteins.
Conclusion
The study demonstrates that intrinsic structural disorder is a common characteristic of hub proteins across four eukaryotic organisms.
Supporting Evidence
- Hub proteins interact with many partners and are more disordered than end proteins.
- The study analyzed datasets from C. elegans, S. cerevisiae, D. melanogaster, and H. sapiens.
- Disorder predictions were made using the PONDR VL-XT method.
Takeaway
This study found that proteins that connect with many other proteins are often disordered, which helps them interact better.
Methodology
The study analyzed protein interaction datasets from four eukaryotic organisms and used PONDR VL-XT for disorder predictions.
Limitations
The definition of hub proteins was somewhat arbitrary, and the results may vary with different datasets.
Statistical Information
P-Value
p<0.05
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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