Targeted enamel remineralization with mineral-loaded starch particles
Author Information
Author(s): Jones Nathan A. PhD, Pan Li-Chi MEng, Flannagan Susan E. MS, Jones Kai A. MD, Lukashova Lyudmila MS, Wightman Lucas BEng, Chang Sywe-Ren MS, Jones Glenn MD, Tenuta Livia M. A. DDS, PhD, González-Cabezas Carlos DDS, PhD, Clarkson Brian H. DDS, PhD, Bloembergen Wendy MD, Bloembergen Steven PhD
Primary Institution: GreenMark Biomedical Inc, East Lansing and Ann Arbor, MI; School of Dentistry, University of Michigan, Ann Arbor, MI; Department of Radiology, Montefiore Medical Center, Bronx, NY; Center for Craniofacial Regeneration, School of Dentistry, University of Pittsburgh, Pittsburgh, PA; School of Medicine, Saba University, Devens, MA.
Hypothesis
An alternative approach using mineral-loaded particles designed to target the subsurface of noncavitated caries lesions could be advantageous.
Conclusion
The study shows that mineral-loaded starch particles can effectively remineralize enamel and improve treatment efficacy for early caries.
Supporting Evidence
- MLCS-FP and MLCS-FF treatments restored 42.9% and 38.6% mineral density, respectively.
- Visual assessments showed significant improvement in lesion appearance with MLCS treatments compared to controls.
- Statistical analysis confirmed that MLCS treatments were superior to fluoride and negative controls.
Takeaway
This study found that special particles can help fix early tooth decay by delivering minerals right where they're needed.
Methodology
Mineral-loaded cationic starch particles were tested on natural caries lesions in extracted human teeth using various imaging and assessment techniques.
Potential Biases
Potential bias from the unblinded treatment application and variability in biological samples.
Limitations
The study was in vitro, which may not fully represent clinical outcomes, and only smooth-surface lesions were evaluated.
Participant Demographics
Deidentified human teeth from anonymous donors were used.
Statistical Information
P-Value
P < .05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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