Early Detection of Oral Cancer Using PAP and AgNOR Staining
Author Information
Author(s): Dinesh V Rajput, Jagdish V Tupkari
Primary Institution: Government Dental College and Hospital, Mumbai
Hypothesis
The study aims to determine the diagnostic accuracy of routine Papanicolaou stain (PAP) and AgNOR staining in brush biopsies for early detection of oral cancer.
Conclusion
Brush biopsy combined with AgNOR staining is a reliable and non-invasive method for early detection of oral cancerous lesions.
Supporting Evidence
- The sensitivity of PAP analysis for detecting oral cancer was 91.176% and specificity was 100%.
- AgNOR analysis showed 100% sensitivity and specificity for detecting oral cancer.
- Positive predictive value for both PAP and AgNOR was 100%.
Takeaway
Doctors can use a simple brush to collect cells from the mouth and then stain them to check for cancer, which is easier and safer than traditional methods.
Methodology
Brush biopsies were taken from 34 patients with suspicious oral lesions and 10 control subjects, followed by PAP and AgNOR staining for analysis.
Limitations
Further investigations with a larger sample size are needed to confirm the findings.
Participant Demographics
34 patients with suspected oral cancer and 10 normal-aged and sex-matched controls.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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