Cross-Talk between Apolipoprotein E and Cytokines
2011
The Role of Apolipoprotein E in Inflammation and Immune Response
publication
Evidence: moderate
Author Information
Author(s): Hongliang Zhang, Li-Min Wu, Jiang Wu
Primary Institution: The First Hospital of Jilin University, Jilin University; Karolinska Institute, Karolinska University Hospital
Hypothesis
Apolipoprotein E (apoE) modulates inflammation and immune responses in an isoform-dependent manner.
Conclusion
Apolipoprotein E plays a crucial role in regulating the balance between proinflammatory and anti-inflammatory responses.
Supporting Evidence
- ApoE is associated with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.
- ApoE can modulate the functions of macrophages and suppress T cell proliferation.
- ApoE influences the production of inflammatory cytokines in response to various stimuli.
Takeaway
Apolipoprotein E helps control inflammation in the body, and different versions of this protein can have different effects.
Digital Object Identifier (DOI)
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