Genetic Variants Affecting Insulin and Glucose Metabolism in Children
Author Information
Author(s): Jan Windholz, Peter Kovacs, Anke Tönjes, Kathrin Dittrich, Susann Blüher, Wieland Kiess, Michael Stumvoll, Antje Körner
Primary Institution: University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
Hypothesis
The study investigates the role of four genetic loci (ADCY5, GIPR, GCKR, and VPS13C) in early impairment of glucose and insulin metabolism in children.
Conclusion
The study found that genetic variations in ADCY5 and VPS13C are associated with early impairment of insulin metabolism and blood glucose homeostasis in children.
Supporting Evidence
- The major allele of rs2877716 was associated with decreased fasting plasma insulin and increased insulin sensitivity.
- rs17271305 was associated with lower 2 h blood glucose levels.
- Variants in GIPR and GCKR showed no significant associations with glucose or insulin metabolism.
- The study adjusted for age, sex, BMI, and pubertal stage in its analyses.
Takeaway
Some kids have genes that can make it harder for their bodies to handle sugar and insulin, which can lead to health problems later on.
Methodology
The study genotyped four genetic variants in 638 Caucasian children and assessed their associations with glucose and insulin metabolism through detailed metabolic testing.
Limitations
The associations found did not withstand correction for multiple testing, likely due to the small sample size.
Participant Demographics
The study included 638 Caucasian children, with a mean age of 11.5 years, and a mix of obese and healthy lean controls.
Statistical Information
P-Value
0.008, 0.009, 0.016, 0.013, 0.009
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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