Obesity and Gallbladder Issues in Male Mice on High-Protein and Fat Diets
Author Information
Author(s): Miyasaka Kyoko, Kanai Setsuko, Ohta Minoru, Sekime Ayako, Akimoto Saeko, Takiguchi Soichi, Funakoshi Akihiro
Primary Institution: Tokyo Metropolitan Institute of Gerontology
Hypothesis
Is there a sex-related risk factor in the manifestation of metabolic syndrome and gallstone formation in mice?
Conclusion
Male mice were more susceptible to protein- and fat-enriched diet-induced obesity than female mice, and hyper-nutritional status accelerated sludge and gallstone formation in male mice.
Supporting Evidence
- Male mice fed a high-protein and fat diet gained more weight than those on a standard diet.
- Gallstone formation was observed in male mice on the high-protein and fat diet at 6 months of age.
- Female mice did not show significant differences in weight or gallstone formation between diets.
Takeaway
This study found that male mice get fatter and have more gallbladder problems when they eat a diet high in protein and fat compared to female mice.
Methodology
The study used CCK-1R gene knockout mice to compare the effects of a high-protein and fat diet on body weight, plasma lipids, and gallstone formation between male and female mice.
Participant Demographics
Male and female CCK-1R gene knockout and wild-type mice.
Statistical Information
P-Value
p=0.004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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