Bile Reflux Index After Therapeutic Biliary Procedures
Author Information
Author(s): Kuran Sedef, Parlak Erkan, Aydog Gulden, Kacar Sabite, Sasmaz Nurgul, Ozden Ali, Sahin Burhan
Primary Institution: Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
Hypothesis
How do therapeutic biliary procedures affect the histology-based bile reflux index (BRI)?
Conclusion
Therapeutic biliary procedures increase the rate of bile reflux index positivity, especially in patients who underwent choledochoduodenostomy.
Supporting Evidence
- 45% of the subjects were positive for Helicobacter pylori.
- 74.3% of bile reflux index positive status was found in antrum specimens from Helicobacter pylori negative biliary group patients.
- 100% of the Billroth II gastroenterostomy group had positive bile reflux index in the corpus.
Takeaway
This study found that patients who had certain biliary surgeries are more likely to have bile reflux, which can cause stomach problems.
Methodology
Biopsies were taken from the gastric antrum and corpus of 131 subjects, and the bile reflux index was calculated based on histological parameters.
Potential Biases
Potential bias due to the exclusion criteria and the specific patient population studied.
Limitations
The study did not evaluate the long-term effects of bile reflux or the impact of other potential confounding factors.
Participant Demographics
56 men and 75 women, mean age 55.9 ± 15.6 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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