Natural Inhibitors and the PI3K/PDK1/PKB Pathway in Insulin Signaling
Author Information
Author(s): Cho Jae Youl, Park Jongsun
Primary Institution: Kangwon National University, Chuncheon, Korea; Chungnam National University, Taejeon, South Korea
Hypothesis
Natural products can enhance our understanding of the insulin-mediated signaling pathway involving PI3K, PDK1, and PKB.
Conclusion
Natural inhibitors have significantly advanced our understanding of the molecular mechanisms of insulin action in the PI3K/PDK1/PKB signaling pathway.
Supporting Evidence
- Natural products can be toxic but provide insights into insulin signaling mechanisms.
- Natural inhibitors like wortmannin and geldanamycin have been shown to affect insulin signaling pathways.
- Understanding these pathways can lead to the development of new treatments for diabetes.
Takeaway
This study looks at how certain natural substances help us understand how insulin works in our bodies, especially in controlling blood sugar.
Methodology
The review discusses various natural inhibitors and their effects on the PI3K/PDK1/PKB signaling pathway based on existing molecular studies.
Limitations
The natural products discussed are often toxic and cannot be used as treatments for insulin-related diseases in humans.
Digital Object Identifier (DOI)
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