Impact of Metabolic Risk Factors on Gastro-Oesophageal Reflux Disease
Author Information
Author(s): Lee Y-C, Yen A M-F, Tai J J, Chang S-H, Lin J-T, Chiu H-M, Wang H-P, Wu M-S, Chen T H-H
Primary Institution: National Taiwan University
Hypothesis
The study aims to quantify the effect of metabolic risk factors on the natural course of gastro-oesophageal reflux disease (GORD).
Conclusion
Metabolic syndrome is linked to faster progression to erosive disease and slower regression from it, highlighting the need for targeted prevention strategies.
Supporting Evidence
- 12.2%, 14.9%, and 17.9% of subjects progressed from non-erosive to erosive disease over three study periods.
- 42.5%, 37.3%, and 34.6% of subjects regressed to the non-erosive stage during the same periods.
- Being male increased the likelihood of disease progression with a relative risk of 4.31.
Takeaway
This study shows that being overweight, male, or having metabolic syndrome can make it more likely for people to develop serious acid reflux problems.
Methodology
The study used a three-state Markov model to analyze data from subjects undergoing repeated upper endoscopy.
Potential Biases
Potential bias due to self-reported data and exclusion of certain patient groups.
Limitations
The study did not include long-term users of proton pump inhibitors or histamine-2 receptor antagonists, which may limit generalizability.
Participant Demographics
Mean age was 56.3 years, with 67.7% male and 11.3% smokers.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 0.136 to 0.165
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website