Muscle Phosphodiesters in Type 2 Diabetes
Author Information
Author(s): Szendroedi Julia, Schmid Albrecht Ingo, Chmelik Marek, Krssak Martin, Nowotny Peter, Prikoszovich Thomas, Kautzky-Willer Alexandra, Wolzt Michael, Waldhäusl Werner, Roden Michael
Primary Institution: Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich-Heine University Düsseldorf
Hypothesis
Myocellular phosphodiesters (PDE) are increased in patients with type 2 diabetes and correlate inversely with mitochondrial ATP turnover.
Conclusion
Muscular PDE concentrations associate with age, lower resting mitochondrial activity, and insulin resistance, primarily determined by body mass and glycemia.
Supporting Evidence
- During fasting, T2D and CONm had 1.5 fold greater PDE than CONy.
- PDE correlated negatively with insulin sensitivity and mitochondrial ATP turnover.
- PDE levels were higher in middle-aged patients with T2D compared to young non-diabetic humans.
Takeaway
People with type 2 diabetes have higher levels of certain muscle substances that are linked to age and how well their bodies use insulin.
Methodology
A cross-sectional study measuring myocellular PDE and mitochondrial activity in patients with type 2 diabetes and healthy controls using magnetic resonance spectroscopy.
Potential Biases
The study's cohort included a mix of normal weight, overweight, and obese individuals, which may affect generalizability.
Limitations
No biopsies were taken to identify individual components of the PDE peak, and no indicators of oxidative stress were determined.
Participant Demographics
10 nonobese middle-aged patients with type 2 diabetes, 10 healthy age-matched controls, and 18 young healthy controls.
Statistical Information
P-Value
0.004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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