Role of CapG Protein in Oral Cancer
Author Information
Author(s): Nomura Hitomi, Uzawa Katsuhiro, Ishigami Takashi, Kouzu Yukinao, Koike Hirofumi, Ogawara Katsunori, Siiba Masashi, Bukawa Hiroki, Yokoe Hidetaka, Kubosawa Hitoshi, Tanzawa Hideki
Primary Institution: Chiba University
Hypothesis
Is CapG protein expression associated with oral carcinogenesis?
Conclusion
CapG is frequently overexpressed in premalignant and malignant oral lesions, suggesting its potential as a biomarker and therapeutic target for oral squamous cell carcinoma.
Supporting Evidence
- 52% of OSCC cases showed increased CapG expression.
- 64% of OPL cases exhibited positive CapG immunoreactivity.
- CapG expression correlated with advanced clinical disease stage.
Takeaway
This study found that a protein called CapG is found in higher amounts in cancerous and precancerous mouth tissues, which might help doctors find and treat oral cancer better.
Methodology
Immunohistochemistry and qRT-PCR were used to analyze CapG expression in tissue samples from 79 OSCCs and 28 OPLs.
Participant Demographics
Patients with oral squamous cell carcinoma and oral premalignant lesions.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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