Anti-Tumor Activity of Gold Complexes
Author Information
Author(s): Lorraine K. Webster, Silvina Rainone, Ernst Horn, Edward R.T. Tiekink
Primary Institution: Peter MacCallum Cancer Institute
Hypothesis
Can triphenylphosphinegold(I) thionucleobases effectively inhibit tumor growth in vitro and in vivo?
Conclusion
The [Ph3PAu(6-MP)] complex significantly reduced tumor size in mice, demonstrating potential as an anti-cancer agent.
Supporting Evidence
- The gold complexes showed excellent growth inhibition activity against the L1210 murine leukaemia in vitro.
- The activity was generally 10 to 100-fold better than for cisplatin and carboplatin.
- [Ph3PAu(6-MP)] led to a 60% reduction in tumor size in mice.
- Cisplatin was able to cure all of the mice in the study.
Takeaway
This study tested gold compounds to see if they could help fight cancer, and one of them worked really well in mice.
Methodology
The study involved in vitro assays on mouse and human cancer cell lines and in vivo tests on mice with tumors.
Limitations
The in vivo results were disappointing compared to cisplatin, and the study did not explore all potential mechanisms of action.
Participant Demographics
Female Balb/c mice, 10-15 weeks old.
Statistical Information
P-Value
0.006
Statistical Significance
p=0.006
Want to read the original?
Access the complete publication on the publisher's website