Timing of Rest Perfusion in MRI Testing
Author Information
Author(s): Vasu Sujethra, Bandettini W Patricia, Hsu Li-Yueh, Kellman Peter, Wilson Joel, Leung Steve, Shanbhag Sujata M, Booker O Julian, Mancini Christine, Henry Jennifer, Lowrey Tracy, Arai Andrew E
Primary Institution: National Institutes of Health, Bethesda, MD, USA
Hypothesis
Rest perfusion performed 20 minutes after regadenoson stress and reversal with aminophylline is higher than rest perfusion before administration of regadenoson.
Conclusion
Rest perfusion done 20 minutes after regadenoson has not returned to baseline, leading to an underestimation of myocardial perfusion reserve.
Supporting Evidence
- Rest 2 MBF was 1.43 ± 0.10, higher than Rest 1 which was 1.18 ± 0.07.
- Stress MBF was measured at 3.72 ± 0.18.
- Using Rest 2 as true resting perfusion leads to a 15% underestimation of MPR.
Takeaway
This study looked at how well heart imaging after a stress test reflects normal heart function, finding that it doesn't go back to normal as expected.
Methodology
Seventeen healthy volunteers underwent stress testing with regadenoson, followed by rest imaging 20 minutes later to assess myocardial blood flow.
Participant Demographics
Healthy normal volunteers with Framingham score less than 1%.
Statistical Information
P-Value
p=0.009
Statistical Significance
p=0.005
Digital Object Identifier (DOI)
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