Reduction of transmural oesophageal variceal pressure by metoclopramide
1991
Does Metoclopramide Reduce Variceal Pressure?
Sample size: 19
publication
Evidence: moderate
Author Information
Author(s): G. Kleber, T. Sauerbruch, G. Fischer, G. Geigenberger, G. Paumgartner
Hypothesis
Does metoclopramide reduce transmural oesophageal variceal pressure in patients with portal hypertension?
Conclusion
Metoclopramide significantly reduced the variceal blood pressure in patients with portal hypertension.
Supporting Evidence
- Metoclopramide reduced variceal pressure by 17.6 ± 18.6%.
- No change in pressure was observed after placebo.
Takeaway
Metoclopramide can help lower the pressure in swollen veins in the esophagus, which can prevent bleeding.
Methodology
The study measured variceal blood pressure in patients before and after administering metoclopramide or placebo.
Limitations
The study had a small sample size and did not include a diverse patient population.
Participant Demographics
Nineteen patients with portal hypertension and oesophageal varices.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
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