Interaction of TFIZ1 and TFF1 in Gastric Cancer
Author Information
Author(s): May Felicity E.B., Griffin S. Michael, Westley Bruce R.
Primary Institution: University of Newcastle upon Tyne
Hypothesis
The study investigates the binding and co-expression of TFIZ1 and TFF1 in normal gastric mucosa and gastric cancer.
Conclusion
The co-expression of TFIZ1 and TFF1 is disrupted in gastric cancer, with TFF1 expression in the absence of TFIZ1 being associated with a more invasive cancer phenotype.
Supporting Evidence
- TFIZ1 and TFF1 are co-expressed in normal gastric mucosa.
- TFIZ1 expression is lost early in gastric cancer.
- TFF1 can be expressed in the absence of TFIZ1 in cancer cells.
- The presence of TFF1 without TFIZ1 is linked to lymph node metastasis.
Takeaway
This study shows that two proteins, TFIZ1 and TFF1, work together in healthy stomach cells, but in cancer, they often don't work together anymore, which might make the cancer worse.
Methodology
The study involved immunohistochemistry and co-immunoprecipitation to analyze the expression and interaction of TFIZ1 and TFF1 in gastric samples.
Limitations
The study is limited to the analysis of protein expression and does not explore the underlying genetic mechanisms.
Participant Demographics
The study involved gastric samples from 15 individuals with gastric cancer.
Statistical Information
P-Value
0.007
Statistical Significance
p=0.007
Digital Object Identifier (DOI)
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