Plasma Neutrophil Elastase and Elafin Imbalance in ARDS
Author Information
Author(s): Wang Zhaoxi, Chen Feng, Zhai Rihong, Zhang Lingsong, Su Li, Lin Xihong, Thompson Taylor, Christiani David C.
Primary Institution: Harvard School of Public Health
Hypothesis
An imbalance between neutrophil elastase (HNE) and its inhibitors in blood is related to the development of ARDS.
Conclusion
Plasma profiles of PI3, HNE, and HNE/PI3 may be useful clinical biomarkers in monitoring the development of ARDS.
Supporting Evidence
- The ARDS patients had higher HNE but lower PI3 at the onset of ARDS.
- The HNE/PI3 ratio was significantly higher in ARDS patients compared to controls.
- Plasma profiles of PI3 and HNE correlated with the severity of ARDS.
Takeaway
This study found that when people develop a serious lung condition called ARDS, the balance of certain proteins in their blood gets disrupted, which could help doctors track the disease.
Methodology
Plasma levels of PI3, SLPI, and HNE were measured in samples from ARDS patients and at-risk controls.
Limitations
The sample size was relatively small, especially in the pre-ARDS group.
Participant Demographics
The study included 148 ARDS patients and 63 critically ill patients at risk for ARDS.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI, 10.9–19.4
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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