Comparing ThinPrep and Conventional Pap Smears for Cervical Cancer Screening
Author Information
Author(s): J Monsonego, A Autillo-Touati, C Bergeron, R Dachez, J Liaras, J Saurel, L Zerat, P Chatelain, C Mottot
Primary Institution: Institut Alfred Fournier
Hypothesis
Is ThinPrep fluid-based cytology more effective than conventional Papanicolaou smear for cervical cancer screening?
Conclusion
The ThinPrep Pap Test is more accurate than the conventional Pap test and can improve primary cervical cancer screening.
Supporting Evidence
- 29% more ASCUS cases were detected on ThinPrep slides than on conventional smears.
- 39% more low-grade squamous intraepithelial lesions (LSIL) were detected on ThinPrep slides.
- 50% more LSIL and 18% more high-grade SIL (HSIL) were found using ThinPrep.
Takeaway
This study found that a new way of testing for cervical cancer is better at finding problems than the old way.
Methodology
A six-centre, split-sample study comparing ThinPrep fluid-based cytology to conventional Pap smears with blinded screening.
Participant Demographics
Patients were over 18 years old with intact cervix and provided informed consent.
Statistical Information
P-Value
0.001
Statistical Significance
p=0.001
Digital Object Identifier (DOI)
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