Assessment of the Role of Renal Organic Anion Transporters in Drug-Induced Nephrotoxicity
2010
Role of Renal Organic Anion Transporters in Drug-Induced Nephrotoxicity
publication
Evidence: moderate
Author Information
Author(s): Hagos Yohannes, Wolff Natascha A.
Primary Institution: Georg-August-Universität Göttingen
Hypothesis
The review assesses the involvement of organic anion transporters (OATs) in drug-induced renal damage in humans.
Conclusion
The study highlights the critical role of OATs in mediating nephrotoxic effects of various drugs.
Supporting Evidence
- OATs can mediate direct cellular toxicity by allowing harmful drugs to enter kidney cells.
- Certain drugs can cause kidney stones by precipitating in the urine.
- High levels of blood-borne substances can increase the risk of kidney injury from drugs.
Takeaway
Some medicines can hurt your kidneys, and special helpers in your body called transporters can make this happen. This study looks at how these helpers work.
Methodology
The review discusses various drugs known to interact with OATs and their nephrotoxic potential.
Limitations
The review may not cover all potential nephrotoxic drugs or all mechanisms of nephrotoxicity.
Digital Object Identifier (DOI)
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