BETA-HYDROXYBUTYRATE IS A METABOLIC REGULATOR OF PROTEOSTASIS IN THE AGING BRAIN
2024
Beta-Hydroxybutyrate and Brain Health
publication
Evidence: moderate
Author Information
Author(s): Madhavan Sidharth, Diaz Stephanie Roa, Nomura Mitsunori, King Christina, Garcia Thelma, Schilling Birgit, Chaudhuri Asish, Newman John
Primary Institution: Buck Institute for Research on Aging
Hypothesis
Can beta-hydroxybutyrate act as a metabolic regulator of proteostasis in the aging brain?
Conclusion
Beta-hydroxybutyrate helps maintain protein stability in the brain and may alleviate Alzheimer's disease pathology.
Supporting Evidence
- Beta-hydroxybutyrate acts as a molecular chaperone regulating protein solubility in the brain.
- The study demonstrated BHB-chaperone activity in various mouse systems.
- BHB selectively targets pathological proteins like amyloid-beta.
- Exogenous BHB reduces amyloid-beta aggregation toxicity in nematode models.
- A comprehensive atlas of BHB-induced protein changes was created using mass spectrometry.
Takeaway
Beta-hydroxybutyrate is like a helper that keeps proteins in the brain from getting messy as we age.
Methodology
The study used in vitro, ex vivo, and in vivo mouse systems to investigate the effects of beta-hydroxybutyrate.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website