Role of VEGF in Mesothelioma Tumors
Author Information
Author(s): Ohta Y, Shridhar V, Bright R K, Kalemkerian G P, Du W, Carbone M, Watanabe Y, Pass H I
Primary Institution: Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
Hypothesis
The study investigates the connection and prognostic value of VEGF and VEGF type C in malignant pleural mesothelioma.
Conclusion
VEGF and VEGF-C are important in the development of blood and lymph vessels in malignant pleural mesothelioma, and their levels may serve as prognostic indicators.
Supporting Evidence
- VEGF and VEGF-C expression levels were high in all MPM cell lines.
- 31.5% of tumors had higher VEGF expression compared to normal tissues.
- 66.7% of tumors had higher VEGF-C expression compared to normal tissues.
- Significant positive correlations were found between VEGF-C and flt-4.
- VD was a negative prognostic indicator in this study.
Takeaway
This study found that certain proteins help tumors grow new blood and lymph vessels, which can be important for understanding how to treat mesothelioma.
Methodology
The study assessed mRNA expression of VEGF, VEGF-C, and their receptors in MPM cell lines and tumors using reverse transcriptase PCR and immunohistochemical staining.
Participant Demographics
The study included 54 malignant pleural mesothelioma tumors, four human MPM cell lines, and five normal pleural tissues.
Statistical Information
P-Value
< 0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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