Domain-Domain Interactions Underlying Herpesvirus-Human Protein-Protein Interaction Networks
2011
Understanding Herpesvirus-Human Protein Interactions
publication
Evidence: high
Author Information
Author(s): Itzhaki Zohar
Primary Institution: The Hebrew University of Jerusalem
Hypothesis
Do conserved domain-domain interactions mediate host-virus interaction networks?
Conclusion
The study found that specific domain-pairs mediate significant fractions of human-virus protein interactions.
Supporting Evidence
- Statistically significant fractions of human-virus interactions can be attributed to conserved domain-domain interactions.
- Viral domains tend to interact with human hub domains, which may help the virus interfere with various human processes.
- The study provides a dataset of viral and human domains involved in herpesvirus infection.
Takeaway
This study shows that viruses can use parts of human proteins to interact with human cells, which helps them survive and thrive.
Methodology
The study analyzed protein-protein interactions using datasets of host-virus interactions and domain-pair interactions.
Statistical Information
P-Value
<0.001
Statistical Significance
<0.001
Digital Object Identifier (DOI)
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