Genetic Variation in Laminin Gene Affects Body Composition in Drosophila and Humans
Author Information
Author(s): De Luca Maria, Chambers Michelle, Casazza Krista, Lok Kerry H, Hunter Gary R, Gower Barbara A, Fernández José R
Primary Institution: University of Alabama at Birmingham
Hypothesis
Does natural variation in the LAMA5 gene affect body composition in humans?
Conclusion
The study suggests that genetic variation in the LAMA5 gene contributes to differences in weight and body composition.
Supporting Evidence
- Four candidate genes were identified that influence TAG storage in Drosophila.
- SNP rs659822 was associated with weight and lean mass in both European American and African American women.
- SNP rs944895 was associated with serum TAG levels and HDL-cholesterol in African American women.
Takeaway
Scientists studied fruit flies and found that a gene called LAMA5 affects how much fat and weight people have. This means our genes can influence our body shape.
Methodology
The study used quantitative complementation tests in Drosophila and a human population-based association study to investigate the effects of LAMA5 gene variants.
Potential Biases
Potential confounding factors related to genetic admixture were controlled for, but the sample was not diverse in terms of gender.
Limitations
The human study had a small sample size and was restricted to women.
Participant Demographics
228 unrelated pre-menopausal women, including 101 European Americans and 127 African Americans.
Statistical Information
P-Value
EA: P = 0.008; AA: P = 0.05
Digital Object Identifier (DOI)
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