The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products
Author Information
Author(s): Barrera Giuseppina, Toaldo Cristina, Pizzimenti Stefania, Cerbone Angelo, Pettazzoni Piergiorgio, Dianzani Mario Umberto, Ferretti Carlo
Primary Institution: Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Patologia Generale, Torino, Italy
Conclusion
PPAR ligands can inhibit cell growth and promote differentiation and apoptosis in various cell types.
Supporting Evidence
- PPAR ligands have been shown to inhibit cell growth in various cancer cell lines.
- Activation of PPARγ ligands induces apoptosis in human colorectal cancer cells.
- PPARα and PPARγ ligands promote differentiation in leukemic cells.
- HNE enhances the effects of PPAR ligands on cell growth inhibition.
- Different PPAR ligands have varying effects on cell types, indicating specificity.
Takeaway
This study looks at how certain molecules called PPAR ligands can help control how cells grow and die, which is important for understanding diseases like cancer.
Methodology
The review summarizes various studies on PPAR ligands and their effects on gene expression, cell growth, differentiation, and apoptosis.
Limitations
The review does not provide new experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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