Genetics of Haemorrhagic Stroke
Author Information
Author(s): Peck George, Smeeth Liam, Whittaker John, Casas Juan Pablo, Hingorani Aroon, Sharma Pankaj
Primary Institution: Imperial College London
Hypothesis
What is the genetic basis of haemorrhagic stroke?
Conclusion
The study suggests a genetic contribution to some types of haemorrhagic stroke, supporting a polygenic aetiology.
Supporting Evidence
- 6,359 cases and 13,805 controls were included in the meta-analysis.
- Statistically significant associations were found for the ACE/I allele and SERPINE1 4G/5G polymorphism.
- APOE ε2 and ε4 alleles were significantly associated with lobar haemorrhage.
Takeaway
Some genes can make people more likely to have a type of stroke called haemorrhagic stroke, but it's not just one gene; many genes work together.
Methodology
A systematic review and meta-analysis of genetic studies in haemorrhagic stroke was conducted, analyzing odds ratios and confidence intervals for gene-disease associations.
Potential Biases
Concerns about spurious associations and inadequate statistical power due to small sample sizes in some studies.
Limitations
The evidence base is smaller compared to ischaemic stroke, and the study's findings are limited by the available data and variability in study methodologies.
Participant Demographics
The study included adults with a focus on Caucasian populations, with some studies from various ethnic backgrounds.
Statistical Information
P-Value
0.0003
Confidence Interval
1.20–1.83
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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